![]() Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. In all patients, we found a highly significant correlation between the logarithm of EPO (log) and the hemoglobin (Hb) level. These results were compared with those obtained from appropriate control groups. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). ![]() In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. ![]() On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors.
0 Comments
Leave a Reply. |